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JAK2 (Janus kinase-2) is a protein kinase that is associated with the PRLR through binding to the box 1 motif. Its activation is the first intracellular event. Jak2 is widely expressed in many tissues. It is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin. JAK2 kinase is a member of a family of tyrosine kinases involved in cytokine receptor signaling. See for background information on Janus kinases.

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JAK2 was shown to be required for the SDF-1α–induced activation of PI3-kinase and for the tyrosine phosphorylation of multiple focal adhesion proteins. Janus kinase 2 Mutation, Qualitative. Performing Lab: UCSF Molecular Diagnostics Lab. Test Code: JAK2. Technique: PCR / Reverse Dot Blots (RDB. Platform. This is a second-order test that should be used when the test for the JAK2M / JAK2 VF Mutation Detection, Bone Marrow test is negative.

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A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as. JAK2 kinase is a member of a family of tyrosine kinases involved in cytokine receptor signaling. See for background information on Janus kinases. BACKGROUND: The VF mutation, which causes the substitution of phenylalanine for valine at position of the Janus kinase (JAK) 2 gene (JAK2), is often.